Wednesday 01 April 2009 |
Morning |
09:00 |
Registration and placing of posters |
10:30 |
Welcome (Christopher Bachran) |
10:45 |
Opening Talk
Christopher Bachran
(Charité, Berlin, Germany)
Targeted Therapy — past, present, and future |
Chair: Christopher Bachran |
11:15 |
Luzie Fabisch Memorial Lecture
 Arthur E. Frankel
(Cancer Research Institute of Scott & White, Temple, TX, USA)
Recombinant toxin therapy of leukemia |
12:00 |
Daniel Vallera
(University of Minnesota Cancer Center, Minneapolis, MN, USA)
Genetic design of new bispecific fusion toxins for carcinoma therapy
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12:35 |
Dafne Müller
(University Stuttgart, Germany)
Bispecific and bifunctional antibody molecules for targeted cancer immunotherapy
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12:55 |
Maria Serena Fabbrini
(Consiglio Nazionale Delle Ricerche, Milan, Italy)
Pichia pastoris as a host for secretion of saporin-based chimeras with anti-cancer potential |
13:15 |
Coffee, snack & posters |
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Wednesday 01 April 2009 |
Afternoon |
Chair: Stefan Barth |
15:00 |
Ursula Elsässer-Beile
(University Hospital Freiburg, Germany)
New targeted therapies against prostate cancer with PSMA-specific immunotoxins and diabodies |
15:35 |
Marco Colombatti
(Policlinico "G.B. Rossi", Verona, Italy)
Immunotoxins to prostate tumors |
16:10 |
Mehmet K. Tur
(Helmholtz-Institute for Biomedical Engineering, University Hospital RWTH Aachen, Germany)
Immunokinases, a novel class of immunotherapeutics for targeted cancer treatment |
16:45 |
Winfried Wels
(Georg-Speyer-Haus, Frankfurt, Germany)
Targeted induction of apoptosis by immunotoxin-like fusion proteins employing human effector functions |
17:20 |
Coffee break |
Chair: Michael G. Rosenblum |
17:45 |
Hans Bäumler
(Charité, Berlin, Germany)
Red blood cells as carriers for targeted drug delivery to tumor cells |
18:20 |
Andrew Thorburn
(University of Colorado Denver, Aurora, CO, USA)
Manipulation of other processes to improve the effectiveness of tumor-targeted toxins |
18:55 |
Mark Sutherland
(University of Bradford, UK)
Cytochrome P450 specific activation of prodrug ultrapotent chemotherapeutics
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19:30 |
Get together & posters |
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Free time to explore Berlin by night |
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Thursday 02 April 2009 |
Morning |
Chair: Kuslima Shogen |
08:30 |
Walter A. Hall
(SUNY Upstate Medical University, Syracuse, NY, USA)
Convection enhanced delivery: Neurosurgical issues |
09:15 |
Kuslima Shogen
(Alfacell Corp., Somerset, NJ, USA)
ONCONASE as a cancer drug and targeted payload |
09:50 |
Susanna Rybak
(Bionanomics, LLC, Green Cove Springs, FL, USA)
Integrating extracellular and intracellular specificity |
10:25 |
Coffee break |
10:50 |
Jürgen Krauss
(National Center for Tumor Diseases, Heidelberg, Germany)
Development of immunoRNases for treatment of CD22+ malignancies |
11:25 |
Thomas Schirrmann
(Technical University of Braunschweig, Germany)
Human RNase fusion protein targeting CD30+ tumors |
12:00 |
Claudia De Lorenzo
(University of Napoli, Italy)
Novel human anti-ErbB2 immunoagents |
Chair: Hendrik Fuchs |
12:35 |
Matthias Maak
(Klinikum r. d. Isar, TU München, Germany)
Tumor targeting of colorectal carcinoma and liver metastasis with Shiga toxin B |
12:50 |
Güliz Parmaksiz
(Charité, Berlin, Germany)
In vivo biodistribution and microvascular binding of a high-affinity monoclonal antibody fragment F8-SIP against the extra-domain A of fibronectin |
13:05 |
Marcelo Calderon
(Free University of Berlin, Germany)
Development of macromolecular prodrugs derivated from dendritic polyglycerol |
13:20 |
Lunch & posters |
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Thursday 02 April 2009 |
Afternoon |
Chair: Nicole Schellmann |
14:30 |
Kenneth D. Bagshawe
(Imperial College London, UK)
Antibody-directed enzyme prodrug therapy (ADEPT) |
15:15 |
Markus Deckert
(Charité, Berlin & Klinikum Brandenburg, Germany)
Recombinant fusion proteins for targeted enzyme prodrug therapy in colon and pancreatic cancer |
15:50 |
Kerry Chester
(UCL Cancer Institute, London, UK)
Bench to bedside with recombinant antibody-based cancer therapeutics |
16:25 |
Mini refreshment |
16:50 |
Bus transfer to the Spree |
17:30 |
Boat tour including dinner |
21:30 |
Bus transfer to the hotels |
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Friday 03 April 2009 |
Morning |
Chair: Marco Colombatti |
08:30 |
Masanori Onda
(NIH/NCI, Bethesda, MD, USA)
Strategy to reduce immunogenicity of Pseudomonas exotoxin based immunotoxin |
09:15 |
Stefan Barth
(Fraunhofer-Institute for Molecular Biology and Applied Ecology, Aachen, Germany)
Novel immunotherapeutics for treatment of human diseases |
09:50 |
Ansgar Santel
(Silence Therapeutics AG, Berlin, Germany)
AtuPLEX a novel RNAi-based delivery system for cancer therapies |
10:25 |
Coffee break |
Chair: Steve Leppla |
10:50 |
Hendrik Fuchs
(Charité, Berlin, Germany)
Saponins as tool for drastically improved targeted tumor therapy |
11:25 |
Wijnand Helfrich
(Groningen University, The Netherlands)
Targeting molecules of "life and death" for cancer therapy |
12:00 |
Elke Pogge von Strandmann
(University Hospital Köln, Germany)
NK cell-based immunotherapy of lymphoid malignancies |
12:35 |
Yvonne Andersson
(Cancer Research, Oslo, Norway)
The combination of immunotoxins and the immunosuppressor cyclosporin results in synergistic anti-cancer effects in vitro and in vivo |
12:55 |
Alexander Weng
(Free University of Berlin, Germany)
Mechanistic aspects of the synergistic cytotoxicity between Gypsophila saponins and type I ribosome-inactivating proteins |
13:15 |
Lunch |
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Friday 03 April 2009 |
Afternoon |
Chair: Arthur Frankel |
14:15 |
Michael G. Rosenblum
(University of Texas, Houston, TX, USA)
Development of novel, highly cytotoxic fusion constructs containing granzyme B: Unique mechanisms and functions |
15:00 |
Horst Dürkop
(Charité, Berlin, Germany)
ED-B fibronectin: Neoangiogenesis and drug targeting |
15:35 |
Jochen Probst
(CureVac GmbH, Tübingen, Germany)
Self-adjuvanting messenger RNA-based vaccines as a novel concept in cancer immunotherapy
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15:50 |
Radostina Georgieva
(Charité, Berlin, Germany)
Tumor targeting using magnetite loaded red blood cells
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16:05 |
Steve Leppla
(NIAID, NIH
, Bethesda, MD, USA)
Tumor targeting by protease-activated anthrax toxin proteins |
16:40 |
Concluding remarks (Christopher Bachran) |
17:25 |
Bus transfer to Potsdamer Platz |
18:00 |
Sunset meeting dinner above the buildings of Berlin |
22:00 |
Bus transfer to the hotels |
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